Bisphosphonate-associated osteonecrosis of the jaw is linked to suppressed TGFβ1-signaling and increased Galectin-3 expression: A histological study on biopsies

BACKGROUND: Bisphosphonate associated osteonecrosis of the jaw (BRONJ) implies an impairment in oral hard- and soft tissue repair. An understanding of the signal transduction alterations involved can inform therapeutic strategies. Transforming growth factor β1 (TGFβ1) is a critical regulator of tiss...

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Detalhes bibliográficos
Main Authors: Wehrhan, Falk, Hyckel, Peter, Guentsch, Arndt, Nkenke, Emeka, Stockmann, Phillip, Schlegel, Karl A, Neukam, Friedrich W, Amann, Kerstin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144016/
https://ncbi.nlm.nih.gov/pubmed/21726429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-9-102
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