Sleeping Beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors.

Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic drivers of medulloblastoma and CNS-PNET. Cross-sp...

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Publicado en:Cancer Res
Main Authors: Beckmann, Pauline J., Larson, Jon D., Larsson, Alex T., Ostergaard, Jason P., Wagner, Sandra, Rahrmann, Eric P., Shamsan, Ghaidan A., Otto, George M., Williams, Rory L., Wang, Jun, Lee, Catherine, Tschida, Barbara R., Das, Paramita, Dubuc, Adrian M., Moriarity, Branden S., Picard, Daniel, Wu, Xiaochong, Rodriguez, Fausto J., Rosemarie, Quincy, Krebs, Ryan D., Molan, Amy M., Demer, Addison M., Frees, Michelle M., Rizzardi, Anthony E., Schmechel, Stephen C., Eberhart, Charles G., Jenkins, Robert B., Wechsler-Reya, Robert J., Odde, David J., Huang, Annie, Taylor, Michael D., Sarver, Aaron L., Largaespada, David A.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397665/
https://ncbi.nlm.nih.gov/pubmed/30674530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1261
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