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Curcumin improves exercise performance of mice with coronary artery ligation-induced HFrEF: Nrf2 and antioxidant mechanisms in skeletal muscle

A hallmark of chronic heart failure (HF) with low ejection fraction (HFrEF) is exercise intolerance. We hypothesized that reduced expression of nuclear factor E2-related factor 2 (Nrf2) in skeletal muscle contributes to impaired exercise performance. We further hypothesized that curcumin, a Nrf2 act...

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Bibliographische Detailangaben
Veröffentlicht in:J Appl Physiol (1985)
Hauptverfasser: Wafi, Ahmed M., Hong, Juan, Rudebush, Tara L., Yu, Li, Hackfort, Bryan, Wang, Hanjun, Schultz, Harold D., Zucker, Irving H., Gao, Lie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397404/
https://ncbi.nlm.nih.gov/pubmed/30462567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00654.2018
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