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Disruption of cardiac Med1 inhibits RNA polymerase II promoter occupancy and promotes chromatin remodeling
The Mediator coactivator complex directs gene-specific expression by binding distal enhancer-bound transcription factors through its Med1 subunit while bridging to RNA polymerase II (Pol II) at gene promoters. In addition, Mediator scaffolds epigenetic modifying enzymes that determine local DNA acce...
Gorde:
| Argitaratua izan da: | Am J Physiol Heart Circ Physiol |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Physiological Society
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6397381/ https://ncbi.nlm.nih.gov/pubmed/30461303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00580.2018 |
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