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The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1

RNA polymerase II (PolII) transcribes RNA within a chromatin context, with nucleosomes acting as barriers to transcription. Despite these barriers, transcription through chromatin in vivo is highly efficient, suggesting the existence of factors that overcome this obstacle. To increase the resolution...

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Detalhes bibliográficos
Main Authors: Skene, Peter J, Hernandez, Aaron E, Groudine, Mark, Henikoff, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983905/
https://ncbi.nlm.nih.gov/pubmed/24737864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02042
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