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The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1

RNA polymerase II (PolII) transcribes RNA within a chromatin context, with nucleosomes acting as barriers to transcription. Despite these barriers, transcription through chromatin in vivo is highly efficient, suggesting the existence of factors that overcome this obstacle. To increase the resolution...

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Autors principals: Skene, Peter J, Hernandez, Aaron E, Groudine, Mark, Henikoff, Steven
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983905/
https://ncbi.nlm.nih.gov/pubmed/24737864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02042
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