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Transportan 10 improves the pharmacokinetics and pharmacodynamics of vancomycin

In the presented study, transportan 10 (TP10), an amphipathic cell penetrating peptide (CPP) with high translocation activity, was conjugated with vancomycin (Van), which is known for poor access to the intracellular bacteria and the brain. The antibacterial activity of the conjugates was tested on...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Ruczyński, Jarosław, Rusiecka, Izabela, Turecka, Katarzyna, Kozłowska, Agnieszka, Alenowicz, Magdalena, Gągało, Iwona, Kawiak, Anna, Rekowski, Piotr, Waleron, Krzysztof, Kocić, Ivan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397271/
https://ncbi.nlm.nih.gov/pubmed/30824786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40103-w
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