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Ras-Specific GTPase-Activating Proteins—Structures, Mechanisms, and Interactions
Ras-specific GTPase-activating proteins (RasGAPs) down-regulate the biological activity of Ras proteins by accelerating their intrinsic rate of GTP hydrolysis, basically by a transition state stabilizing mechanism. Oncogenic Ras is commonly not sensitive to RasGAPs caused by interference of mutants...
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| Publicado no: | Cold Spring Harb Perspect Med |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6396337/ https://ncbi.nlm.nih.gov/pubmed/30104198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031500 |
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