Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities

[Image: see text] Up to ∼20% of HIV-infected individuals eventually develop broadly neutralizing antibodies (bnAbs), and many of these antibodies (∼40%) target a region of dense high-mannose glycosylation on gp120 of the HIV envelope protein, known as the “high-mannose patch” (HMP). Thus, there have...

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Publicado en:ACS Cent Sci
Autores principales: Nguyen, Dung N., Xu, Bokai, Stanfield, Robyn L., Bailey, Jennifer K., Horiya, Satoru, Temme, J. Sebastian, Leon, Deborah R., LaBranche, Celia C., Montefiori, David C., Costello, Catherine E., Wilson, Ian A., Krauss, Isaac J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2019
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6396197/
https://ncbi.nlm.nih.gov/pubmed/30834312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00588
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