Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities

[Image: see text] Up to ∼20% of HIV-infected individuals eventually develop broadly neutralizing antibodies (bnAbs), and many of these antibodies (∼40%) target a region of dense high-mannose glycosylation on gp120 of the HIV envelope protein, known as the “high-mannose patch” (HMP). Thus, there have...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:ACS Cent Sci
Main Authors: Nguyen, Dung N., Xu, Bokai, Stanfield, Robyn L., Bailey, Jennifer K., Horiya, Satoru, Temme, J. Sebastian, Leon, Deborah R., LaBranche, Celia C., Montefiori, David C., Costello, Catherine E., Wilson, Ian A., Krauss, Isaac J.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2019
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6396197/
https://ncbi.nlm.nih.gov/pubmed/30834312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00588
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares