Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities

[Image: see text] Up to ∼20% of HIV-infected individuals eventually develop broadly neutralizing antibodies (bnAbs), and many of these antibodies (∼40%) target a region of dense high-mannose glycosylation on gp120 of the HIV envelope protein, known as the “high-mannose patch” (HMP). Thus, there have...

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Vydáno v:ACS Cent Sci
Hlavní autoři: Nguyen, Dung N., Xu, Bokai, Stanfield, Robyn L., Bailey, Jennifer K., Horiya, Satoru, Temme, J. Sebastian, Leon, Deborah R., LaBranche, Celia C., Montefiori, David C., Costello, Catherine E., Wilson, Ian A., Krauss, Isaac J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6396197/
https://ncbi.nlm.nih.gov/pubmed/30834312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00588
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