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Synthesis of multivalent glycopeptide conjugates that mimic an HIV epitope

Recently, we reported a directed evolution method which enabled us to discover sequences of glycopeptides that bind with picomolar affinity to HIV antibody 2G12 and are of interest as HIV vaccine candidates. In this manuscript, we describe the syntheses of several of these large (~11–12 kDa) glycope...

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Detalhes bibliográficos
Publicado no:Tetrahedron
Main Authors: Bailey, Jennifer K., Nguyen, Dung N., Horiya, Satoru, Krauss, Isaac J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300091/
https://ncbi.nlm.nih.gov/pubmed/28190897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2016.07.062
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