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PTPN2 deficiency along with activation of nuclear Akt predict endocrine resistance in breast cancer
PURPOSE: The protein tyrosine phosphatase, non-receptor type 2 (PTNP2) regulates receptor tyrosine kinase signalling, preventing downstream activation of intracellular pathways like the PI3K/Akt pathway. The gene encoding the protein is located on chromosome 18p11; the 18p region is commonly deleted...
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| Veröffentlicht in: | J Cancer Res Clin Oncol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Berlin Heidelberg
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6394658/ https://ncbi.nlm.nih.gov/pubmed/30515568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-018-2810-6 |
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