The nature of the human T cell response to the cancer antigen 5T4 is determined by the balance of regulatory and inflammatory T cells of the same antigen-specificity: implications for vaccine design

The oncofoetal antigen 5T4 is a promising T cell target in the context of colorectal cancer, as demonstrated by a recent clinical study where 5T4-specific T cell responses, induced by vaccination or cyclophosphamide, were associated with a significantly prolonged survival of patients with metastatic...

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Detalles Bibliográficos
Publicado en:Cancer Immunol Immunother
Main Authors: Besneux, Matthieu, Greenshields-Watson, Alexander, Scurr, Martin J., MacLachlan, Bruce J., Christian, Adam, Davies, Michael M., Hargest, Rachel, Phillips, Simon, Godkin, Andrew, Gallimore, Awen
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2018
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6394487/
https://ncbi.nlm.nih.gov/pubmed/30406375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-018-2266-1
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