Highly prevalent colorectal cancer-infiltrating LAP(+) Foxp3(−) T cells exhibit more potent immunosuppressive activity than Foxp3(+) regulatory T cells

Although elevated CD4(+)Foxp3(+) regulatory T cell (Treg) frequencies within tumors are well documented, the functional and phenotypic characteristics of CD4(+)Foxp3(+) and CD4(+)Foxp3(−) T cell subsets from matched blood, healthy colon, and colorectal cancer require in-depth investigation. Flow cyt...

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Main Authors: Scurr, M, Ladell, K, Besneux, M, Christian, A, Hockey, T, Smart, K, Bridgeman, H, Hargest, R, Phillips, S, Davies, M, Price, D, Gallimore, A, Godkin, A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931584/
https://ncbi.nlm.nih.gov/pubmed/24064667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2013.62
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