Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy

The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in patients. In this study, we prepared angiopep-2 (A2) modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles for TMZ delivery (A2...

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Detalhes bibliográficos
Publicado no:Drug Deliv
Main Authors: Zong, Zhenkun, Hua, Lei, Wang, Zhen, Xu, Haoyue, Ye, Chengkun, Pan, Bomin, Zhao, Zongren, Zhang, Longzhen, Lu, Jun, Liu, Hongmei, Yu, Rutong
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6394306/
https://ncbi.nlm.nih.gov/pubmed/30744436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2018.1534897
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