Activation of radiosensitizers by hypoxic cells.

Hypoxic cells can metabolize nitroheterocyclic compounds to produce toxic intermediates capable of affecting the survival of neighbouring oxygenated cells. Mutagenesis experiments with E. coli WP-2 343 (deficient in nitroreductase) indicated that reduction of nitroheterocyclics outside bacteria caus...

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Bibliographic Details
Main Authors: Olive, P. L., Durand, R. E.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1978
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2149417/
https://ncbi.nlm.nih.gov/pubmed/354676
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