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Activation of radiosensitizers by hypoxic cells.

Hypoxic cells can metabolize nitroheterocyclic compounds to produce toxic intermediates capable of affecting the survival of neighbouring oxygenated cells. Mutagenesis experiments with E. coli WP-2 343 (deficient in nitroreductase) indicated that reduction of nitroheterocyclics outside bacteria caus...

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Bibliografski detalji
Glavni autori: Olive, P. L., Durand, R. E.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1978
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2149417/
https://ncbi.nlm.nih.gov/pubmed/354676
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