Resolution of the Holliday junction recombination intermediate by human GEN1 at the single-molecule level

Human GEN1 is a cytosolic homologous recombination protein that resolves persisting four-way Holliday junctions (HJ) after the dissolution of the nuclear membrane. GEN1 dimerization has been suggested to play key role in the resolution of the HJ, but the kinetic details of its reaction remained elus...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Sobhy, Mohamed A, Bralić, Amer, Raducanu, Vlad-Stefan, Takahashi, Masateru, Tehseen, Muhammad, Rashid, Fahad, Zaher, Manal S, Hamdan, Samir M
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Nucleic Acid Enzymes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393306/
https://ncbi.nlm.nih.gov/pubmed/30590761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1280
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