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A coronary artery disease-associated tRNA(Thr) mutation altered mitochondrial function, apoptosis and angiogenesis
The tissue specificity of mitochondrial tRNA mutations remains largely elusive. In this study, we demonstrated the deleterious effects of tRNA(Thr) 15927G>A mutation that contributed to pathogenesis of coronary artery disease. The m.15927G>A mutation abolished the highly conserved base-pairing...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6393294/ https://ncbi.nlm.nih.gov/pubmed/30541130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1241 |
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