A deafness-associated tRNA mutation caused pleiotropic effects on the m(1)G37 modification, processing, stability and aminoacylation of tRNA(Ile) and mitochondrial translation

Defects in the posttranscriptional modifications of mitochondrial tRNAs have been linked to human diseases, but their pathophysiology remains elusive. In this report, we investigated the molecular mechanism underlying a deafness-associated tRNA(Ile) 4295A>G mutation affecting a highly conserved a...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Meng, Feilong, Zhou, Mi, Xiao, Yun, Mao, Xiaoting, Zheng, Jing, Lin, Jiaxi, Lin, Tianxiang, Ye, Zhenzhen, Cang, Xiaohui, Fu, Yong, Wang, Meng, Guan, Min-Xin
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
RNA and RNA-protein complexes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826259/
https://ncbi.nlm.nih.gov/pubmed/33398350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1225
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