Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism

GTPBP3 is a highly conserved tRNA modifying enzyme for the biosynthesis of τm(5)U at the wobble position of mitochondrial tRNA(Glu), tRNA(Gln), tRNA(Lys), tRNA(Trp) and tRNA(Leu(UUR)). The previous investigations showed that GTPBP3 mutations were associated with hypertrophic cardiomyopathy (HCM). Ho...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Chen, Danni, Zhang, Zengming, Chen, Chao, Yao, Shihao, Yang, Qingxian, Li, Feng, He, Xiao, Ai, Cheng, Wang, Meng, Guan, Min-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547414/
https://ncbi.nlm.nih.gov/pubmed/30916346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz218
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