Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis and inflammation in mice

Kupffer cell (KC) and macrophage (MØ) activation contribute to steatosis, inflammation and fibrosis in alcoholic liver disease (ALD). We found increased frequency of MØ, T cells and expression of Ccr2 and Ccr5 in the livers of patients with ALD and increased circulating chemokines, CCL2 and CCL5 in...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Ambade, Aditya, Lowe, Patrick, Kodys, Karen, Catalano, Donna, Gyongyosi, Benedek, Cho, Yeonhee, Vellve, Arvin-Iracheta, Adejumo, Adeyinka, Saha, Banishree, Calenda, Charles, Mehta, Jeeval, Lefebvre, Eric, Vig, Pamela, Szabo, Gyongyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393202/
https://ncbi.nlm.nih.gov/pubmed/30179264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30249
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