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Main constraints for RNAi induced by expressed long dsRNA in mouse cells

RNAi is the sequence-specific mRNA degradation guided by siRNAs produced from long dsRNA by RNase Dicer. Proteins executing RNAi are present in mammalian cells but rather sustain the microRNA pathway. Aiming for a systematic analysis of mammalian RNAi, we report here that the main bottleneck for RNA...

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Foilsithe in:Life Sci Alliance
Main Authors: Demeter, Tomas, Vaskovicova, Michaela, Malik, Radek, Horvat, Filip, Pasulka, Josef, Svobodova, Eliska, Flemr, Matyas, Svoboda, Petr
Formáid: Artigo
Teanga:Inglês
Foilsithe: Life Science Alliance LLC 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6391682/
https://ncbi.nlm.nih.gov/pubmed/30808654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800289
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