USP1 is Required for Replication Fork Protection in BRCA1-Deficient Tumors

BRCA1 deficient tumor cells have defects in homologous-recombination repair and in replication fork stability, resulting in PARP inhibitor sensitivity. Here, we demonstrate that a deubiquitinase, USP1, is upregulated in tumors with mutations in BRCA1. Knockdown or inhibition of USP1 resulted in repl...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Suan Lim, Kah, Li, Heng, Roberts, Emma A., Gaudiano, Emily F., Clairmont, Connor, Sambel, Larissa, Ponnienselvan, Karthikeyan, Liu, Jessica C., Yang, Chunyu, Kozono, David, Parmar, Kalindi, Yusufzai, Timur, Zheng, Ning, D’Andrea, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390489/
https://ncbi.nlm.nih.gov/pubmed/30576655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.10.045
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