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FANCD2 maintains fork stability in BRCA1/2-deficient tumors and promotes alternative end-joining DNA repair

BRCA1/2 proteins function in homologous recombination (HR)-mediated DNA repair and cooperate with Fanconi anemia (FA) proteins to maintain genomic integrity through replication fork stabilization. Loss of BRCA1/2 proteins results in DNA repair deficiency and replicative stress, leading to genomic in...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kais, Zeina, Rondinelli, Beatrice, Holmes, Amie, O’Leary, Colin, Kozono, David, D’Andrea, Alan D., Ceccaldi, Raphael
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939765/
https://ncbi.nlm.nih.gov/pubmed/27264184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.031
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