Mutation in Erythroid Specific Transcription Factor KLF1 Causes Hereditary Spherocytosis in the Nan Hemolytic Anemia Mouse Model

KLF1 regulates definitive erythropoiesis of red blood cells by facilitating transcription through high affinity binding to CACCC elements within its erythroid-specific target genes including those encoding erythrocyte membrane skeleton (EMS) proteins. Deficiencies of EMS proteins in humans lead to t...

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Udgivet i:Genomics
Main Authors: Heruth, Daniel P., Hawkins, Troy, Logsdon, Derek P., Gibson, Margaret I., Sokolovsky, Inna V., Nsumu, Ndona N., Major, Stephanie L., Fegley, Barbara, Woods, Gerald M., Lewing, Karen B., Neville, Kathleen A., Cornetta, Kenneth, Peterson, Kenneth R., White, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390478/
https://ncbi.nlm.nih.gov/pubmed/20691777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygeno.2010.07.009
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