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Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome
Dosage of key regulators impinge on developmental disorders such as FOXG1 syndrome. Since neither knock-out nor knock-down strategy assures flexible and precise protein abundance control, to study hypomorphic or haploinsufficiency expression remains challenging. We develop a system in human pluripot...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6389984/ https://ncbi.nlm.nih.gov/pubmed/30804331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08841-7 |
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