Mutations in Efflux Pump Rv1258c (Tap) Cause Resistance to Pyrazinamide, Isoniazid, and Streptomycin in M. tuberculosis

Although drug resistance in Mycobacterium tuberculosis is mainly caused by mutations in drug activating enzymes or drug targets, there is increasing interest in the possible role of efflux in causing drug resistance. Previously, efflux genes have been shown to be upregulated upon drug exposure or im...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Front Microbiol
Main Authors: Liu, Jiayun, Shi, Wanliang, Zhang, Shuo, Hao, Xiaoke, Maslov, Dmitry A., Shur, Kirill V., Bekker, Olga B., Danilenko, Valery N., Zhang, Ying
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Microbiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389670/
https://ncbi.nlm.nih.gov/pubmed/30837962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00216
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