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Identification of Novel Efflux Proteins Rv0191, Rv3756c, Rv3008, and Rv1667c Involved in Pyrazinamide Resistance in Mycobacterium tuberculosis

Pyrazinamide (PZA) is a critical drug used for the treatment of tuberculosis (TB). PZA is a prodrug that requires conversion to the active component pyrazinoic acid (POA) by pyrazinamidase (PZase) encoded by the pncA gene. Although resistance to PZA is mostly caused by pncA mutations and less common...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Zhang, Yumeng, Zhang, Jia, Cui, Peng, Zhang, Ying, Zhang, Wenhong
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527661/
https://ncbi.nlm.nih.gov/pubmed/28584158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00940-17
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