Clinical significance of plasma cell-free DNA mutations in PIK3CA, AKT1, and ESR1 gene according to treatment lines in ER-positive breast cancer

The somatic activation of PI3K/AKT pathway mutations, PIK3CA and AKT1, and ESR1 mutations in plasma cell-free DNA (cfDNA) has been studied as a non-invasive procedure to quickly assess and monitor disease progression or therapeutic effect in breast cancer (BC) patients, but the clinical significance...

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Bibliographic Details
Published in:Mol Cancer
Main Authors: Takeshita, Takashi, Yamamoto, Yutaka, Yamamoto-Ibusuki, Mutsuko, Tomiguchi, Mai, Sueta, Aiko, Murakami, Keiichi, Iwase, Hirotaka
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Letter to the Editor
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389169/
https://ncbi.nlm.nih.gov/pubmed/29482551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-018-0808-y
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