Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients

BACKGROUND: ESR1 mutations have attracted attention as a potentially important marker and treatment target in endocrine therapy-resistant breast cancer patients. The E380Q mutation, which is one of the ESR1 mutations, is associated with estradiol (E2) hypersensitivity, increased DNA binding to the e...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Takeshita, Takashi, Yamamoto, Yutaka, Yamamoto-Ibusuki, Mutsuko, Sueta, Aiko, Tomiguchi, Mai, Murakami, Keiichi, Omoto, Yoko, Iwase, Hirotaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700624/
https://ncbi.nlm.nih.gov/pubmed/29166868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3779-2
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