Modeling and simulation of the endogenous CYP3A induction marker 4β-hydroxycholesterol during enasidenib treatment

BACKGROUND: Enasidenib (IDHIFA(®), AG-221) is a first-in-class, targeted inhibitor of mutant IDH2 proteins for treatment of relapsed or refractory acute myeloid leukemia. This was a Phase I/II study evaluating safety, efficacy, and pharmacokinetics/pharmacodynamics (PK/PD) of orally administered ena...

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Bibliographic Details
Published in:Clin Pharmacol
Main Authors: Li, Yan, Connarn, Jamie N, Chen, Jian, Tong, Zeen, Palmisano, Maria, Zhou, Simon
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2019
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385784/
https://ncbi.nlm.nih.gov/pubmed/30858735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S192687
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