4β-hydroxycholesterol as an endogenous CYP3A marker in cancer patients treated with taxanes

AIM: Taxanes are anti-cancer agents used to treat several types of solid tumours. They are metabolized by cytochrome P450 (CYP) 3A, displaying a large pharmacokinetic (PK) variability. In this study, we evaluated the endogenous CYP3A4 marker 4β-hydroxycholesterol (4β-OHC) as a potential individual t...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: de Graan, Anne-Joy M, Sparreboom, Alex, de Bruijn, Peter, de Jonge, Evert, van der Holt, Bronno, Wiemer, Erik A C, Verweij, Jaap, Mathijssen, Ron H J, van Schaik, Ron H N
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574840/
https://ncbi.nlm.nih.gov/pubmed/26119961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12707
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