4β-Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin

AIMS: The oxysterol 4β-hydroxycholesterol has been suggested as a marker for CYP3A4/5 activity. We have previously shown that plasma 4β-hydroxycholesterol continues to increase for several weeks after maximal induction of CYP3A4/5 by carbamazepine at the dose given. In the present study we aimed to...

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מידע ביבליוגרפי
Main Authors: Diczfalusy, Ulf, Kanebratt, Kajsa P, Bredberg, Eva, Andersson, Tommy B, Böttiger, Ylva, Bertilsson, Leif
פורמט: Artigo
שפה:Inglês
יצא לאור: Blackwell Science Inc 2009
נושאים:
Pharmacokinetics
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668082/
https://ncbi.nlm.nih.gov/pubmed/19006545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03309.x
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