PIK3CA amplification associates with aggressive phenotype but not markers of AKT-MTOR signaling in endometrial carcinoma

PURPOSE: Amplification of PIK3CA, encoding the PI3K catalytic subunit alpha, is common in uterine corpus endometrial carcinoma (UCEC) and linked to an aggressive phenotype. However, it is unclear whether PIK3CA amplification acts via PI3K activation. We investigated the association between PIK3CA am...

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Pubblicato in:Clin Cancer Res
Autori principali: Holst, Frederik, Werner, Henrica M. J., Mjøs, Siv, Hoivik, Erling A., Kusonmano, Kanthida, Wik, Elisabeth, Berg, Anna, Birkeland, Even, Gibson, William J., Halle, Mari K., Trovik, Jone, Cherniack, Andrew D., Kalland, Karl-Henning, Mills, Gordon B., Singer, Christian F., Krakstad, Camilla, Beroukhim, Rameen, Salvesen, Helga B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6384094/
https://ncbi.nlm.nih.gov/pubmed/30442683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0452
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