PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer

Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer. We sequenced exon9 and exon20 of PIK3CA in 280 primary endometrial cancers to assess the relationship with clinicopathologic variables, patient survival and associations with P...

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Vydáno v:Sci Rep
Hlavní autoři: Mjos, Siv, Werner, Henrica M. J., Birkeland, Even, Holst, Frederik, Berg, Anna, Halle, Mari K., Tangen, Ingvild L., Kusonmano, Kanthida, Mauland, Karen K., Oyan, Anne M., Kalland, Karl-Henning, Lewis, Aurélia E., Mills, Gordon B., Krakstad, Camilla, Trovik, Jone, Salvesen, Helga B., Hoivik, Erling A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578954/
https://ncbi.nlm.nih.gov/pubmed/28860563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10717-z
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