PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer

Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer. We sequenced exon9 and exon20 of PIK3CA in 280 primary endometrial cancers to assess the relationship with clinicopathologic variables, patient survival and associations with P...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Mjos, Siv, Werner, Henrica M. J., Birkeland, Even, Holst, Frederik, Berg, Anna, Halle, Mari K., Tangen, Ingvild L., Kusonmano, Kanthida, Mauland, Karen K., Oyan, Anne M., Kalland, Karl-Henning, Lewis, Aurélia E., Mills, Gordon B., Krakstad, Camilla, Trovik, Jone, Salvesen, Helga B., Hoivik, Erling A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578954/
https://ncbi.nlm.nih.gov/pubmed/28860563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10717-z
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