The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08(+) Rhesus Macaques

Approximately 50% of rhesus macaques (RMs) expressing the major histocompatibility complex class I (MHC-I) allele Mamu-B*08 spontaneously control chronic-phase viremia after infection with the pathogenic simian immunodeficiency virus mac239 (SIVmac239) clone. CD8(+) T-cell responses in these animals...

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Udgivet i:J Virol
Main Authors: Martins, Mauricio A., Gonzalez-Nieto, Lucas, Shin, Young C., Domingues, Aline, Gutman, Martin J., Maxwell, Helen S., Magnani, Diogo M., Ricciardi, Michael J., Pedreño-Lopez, Núria, Bailey, Varian K., Altman, John D., Parks, Christopher L., Allison, David B., Ejima, Keisuke, Rakasz, Eva G., Capuano, Saverio, Desrosiers, Ronald C., Lifson, Jeffrey D., Watkins, David I.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6384082/
https://ncbi.nlm.nih.gov/pubmed/30541854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01626-18
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