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Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching

The hantavirus RNA-dependent RNA polymerase (RdRp) snatches 5′ capped mRNA fragments from the host cell transcripts and uses them as primers to initiate transcription and replication of the viral genome in the cytoplasm of infected cells. Hantavirus nucleocapsid protein (N protein) binds to the 5′ c...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Jeeva, Subbiah, Mir, Sheema, Velasquez, Adrain, Weathers, Brandy A., Leka, Aljona, Wu, Sharon, Sevarany, Ariga Tahmasian, Mir, Mohammad
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6384069/
https://ncbi.nlm.nih.gov/pubmed/30541836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02088-18
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