Crimean-Congo hemorrhagic fever virus nucleocapsid protein harbors distinct RNA-binding sites in the stalk and head domains

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne Nairovirus that causes severe hemorrhagic fever with a mortality rate of up to 30% in certain outbreaks worldwide. The virus has wide endemic distribution. There is no effective antiviral therapeutic or FDA approved vaccine for this zoono...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Jeeva, Subbiah, Mir, Sheema, Velasquez, Adrain, Ragan, Jacquelyn, Leka, Aljona, Wu, Sharon, Sevarany, Ariga Tahmasian, Royster, Austin D., Almeida, Nicholas A., Chan, Fion, O'Brien, Lea, Mir, Mohammad Ayoub
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442043/
https://ncbi.nlm.nih.gov/pubmed/30723154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004976
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