Generation of antibody-based therapeutics targeting the idiotype of B-cell malignancies

BACKGROUND: A feature of many B-cell tumors is a surface-expressed immunoglobulin (sIg). The complementarity-determining regions (CDRs) of the sIg, termed the ‘idiotype’, are unique to each tumor. We report on a phage selection strategy to generate anti-idiotype therapeutics that reacts with sIg CDR...

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Publicat a:Antib Ther
Autors principals: Weiss, Emily, Sarnovsky, Robert, Ho, Mitchell, Arons, Evgeny, Kreitman, Robert, Angelus, Evan, Antignani, Antonella, FitzGerald, David
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383771/
https://ncbi.nlm.nih.gov/pubmed/30801054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abt/tby012
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