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Generation of antibody-based therapeutics targeting the idiotype of B-cell malignancies
BACKGROUND: A feature of many B-cell tumors is a surface-expressed immunoglobulin (sIg). The complementarity-determining regions (CDRs) of the sIg, termed the ‘idiotype’, are unique to each tumor. We report on a phage selection strategy to generate anti-idiotype therapeutics that reacts with sIg CDR...
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| 出版年: | Antib Ther |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6383771/ https://ncbi.nlm.nih.gov/pubmed/30801054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abt/tby012 |
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