Enhancing the cross protective efficacy of live attenuated influenza virus vaccine by supplemented vaccination with M2 ectodomain virus-like particles

Current influenza vaccines including live attenuated influenza virus (LAIV) provide suboptimal protection against drift and potential pandemic strains. We hypothesized that supplementing LAIV with a highly conserved antigenic target M2 ectodomain (M2e) would confer cross-protection by inducing humor...

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Bibliographische Detailangaben
Veröffentlicht in:Virology
Hauptverfasser: Lee, Young-Tae, Kim, Ki-Hye, Ko, Eun-Ju, Kim, Min-Chul, Lee, Yu-Na, Hwang, Hye-Suk, Lee, Youri, Jung, Yu-Jin, Kim, Yu Jin, Santos, Jefferson, Perez, Daniel R., Kang, Sang-Moo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382595/
https://ncbi.nlm.nih.gov/pubmed/30685658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.01.017
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