Intranasal vaccination with M2e5x virus-like particles induces humoral and cellular immune responses conferring cross-protection against heterosubtypic influenza viruses

Current influenza vaccines do not provide broad cross-protection. Here, we report that intranasal vaccination with virus-like particles containing the highly conserved multiple ectodomains of matrix protein 2 (M2e5x VLP) of influenza virus induces broad cross-protection by M2-specific humoral and ce...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Lee, Young-Tae, Ko, Eun-Ju, Lee, Youri, Kim, Ki-Hye, Kim, Min-Chul, Lee, Yu-Na, Kang, Sang-Moo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764335/
https://ncbi.nlm.nih.gov/pubmed/29324805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190868
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