Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. Implicit in this clinicopathologic-based nosology is th...

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Detalhes bibliográficos
Publicado no:Neurology
Main Authors: Espay, Alberto J., Vizcarra, Joaquin A., Marsili, Luca, Lang, Anthony E., Simon, David K., Merola, Aristide, Josephs, Keith A., Fasano, Alfonso, Morgante, Francesca, Savica, Rodolfo, Greenamyre, J. Timothy, Cambi, Franca, Yamasaki, Tritia R., Tanner, Caroline M., Gan-Or, Ziv, Litvan, Irene, Mata, Ignacio F., Zabetian, Cyrus P., Brundin, Patrik, Fernandez, Hubert H., Standaert, David G., Kauffman, Marcelo A., Schwarzschild, Michael A., Sardi, S. Pablo, Sherer, Todd, Perry, George, Leverenz, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
Assuntos:
Medical Hypothesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382364/
https://ncbi.nlm.nih.gov/pubmed/30745444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000006926
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