Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. Implicit in this clinicopathologic-based nosology is th...

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Dades bibliogràfiques
Publicat a:Neurology
Autors principals: Espay, Alberto J., Vizcarra, Joaquin A., Marsili, Luca, Lang, Anthony E., Simon, David K., Merola, Aristide, Josephs, Keith A., Fasano, Alfonso, Morgante, Francesca, Savica, Rodolfo, Greenamyre, J. Timothy, Cambi, Franca, Yamasaki, Tritia R., Tanner, Caroline M., Gan-Or, Ziv, Litvan, Irene, Mata, Ignacio F., Zabetian, Cyrus P., Brundin, Patrik, Fernandez, Hubert H., Standaert, David G., Kauffman, Marcelo A., Schwarzschild, Michael A., Sardi, S. Pablo, Sherer, Todd, Perry, George, Leverenz, James B.
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2019
Matèries:
Medical Hypothesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382364/
https://ncbi.nlm.nih.gov/pubmed/30745444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000006926
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