Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. Implicit in this clinicopathologic-based nosology is th...

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Podrobná bibliografie
Vydáno v:Neurology
Hlavní autoři: Espay, Alberto J., Vizcarra, Joaquin A., Marsili, Luca, Lang, Anthony E., Simon, David K., Merola, Aristide, Josephs, Keith A., Fasano, Alfonso, Morgante, Francesca, Savica, Rodolfo, Greenamyre, J. Timothy, Cambi, Franca, Yamasaki, Tritia R., Tanner, Caroline M., Gan-Or, Ziv, Litvan, Irene, Mata, Ignacio F., Zabetian, Cyrus P., Brundin, Patrik, Fernandez, Hubert H., Standaert, David G., Kauffman, Marcelo A., Schwarzschild, Michael A., Sardi, S. Pablo, Sherer, Todd, Perry, George, Leverenz, James B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Lippincott Williams & Wilkins 2019
Témata:
Medical Hypothesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382364/
https://ncbi.nlm.nih.gov/pubmed/30745444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000006926
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