Development of an Orthotopic Intrasplenic Xenograft Mouse Model of Canine Histiocytic Sarcoma and Its Use in Evaluating the Efficacy of Treatment with Dasatinib

Canine histiocytic sarcoma is a highly aggressive and metastatic hematopoietic neoplasm that responds poorly to currently available treatment regimens. Our goal was to establish a clinically relevant xenograft mouse model to assess the preclinical efficacy of novel cancer treatment protocols for his...

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Detalhes bibliográficos
Publicado no:Comp Med
Main Authors: Takada, Marilia, Smyth, Lauren A, Hix, Jeremy ML, Corner, Sarah M, O'Reilly, Sandra, Kiupel, Matti, Yuzbasiyan-Gurkan, Vilma
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Laboratory Animal Science 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382049/
https://ncbi.nlm.nih.gov/pubmed/30717820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.30802/AALAS-CM-18-000065
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