Loading...
GPN does not release lysosomal Ca(2+) but evokes Ca(2+) release from the ER by increasing the cytosolic pH independently of cathepsin C
The dipeptide glycyl-l-phenylalanine 2-naphthylamide (GPN) is widely used to perturb lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to rupture lysosomal membranes. We show that GPN evokes a sustained increase in lysosomal pH (pH(ly)), and transient increases in cytoso...
Na minha lista:
| Udgivet i: | J Cell Sci |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Company of Biologists Ltd
2019
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6382017/ https://ncbi.nlm.nih.gov/pubmed/30617110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.223883 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|