The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identific...

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Publicat a:Nat Commun
Autors principals: Carmona-Gutierrez, Didac, Zimmermann, Andreas, Kainz, Katharina, Pietrocola, Federico, Chen, Guo, Maglioni, Silvia, Schiavi, Alfonso, Nah, Jihoon, Mertel, Sara, Beuschel, Christine B., Castoldi, Francesca, Sica, Valentina, Trausinger, Gert, Raml, Reingard, Sommer, Cornelia, Schroeder, Sabrina, Hofer, Sebastian J., Bauer, Maria A., Pendl, Tobias, Tadic, Jelena, Dammbrueck, Christopher, Hu, Zehan, Ruckenstuhl, Christoph, Eisenberg, Tobias, Durand, Sylvere, Bossut, Noélie, Aprahamian, Fanny, Abdellatif, Mahmoud, Sedej, Simon, Enot, David P., Wolinski, Heimo, Dengjel, Jörn, Kepp, Oliver, Magnes, Christoph, Sinner, Frank, Pieber, Thomas R., Sadoshima, Junichi, Ventura, Natascia, Sigrist, Stephan J., Kroemer, Guido, Madeo, Frank
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381180/
https://ncbi.nlm.nih.gov/pubmed/30783116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08555-w
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