3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB

Abstract Caloric restriction mimetics (CRMs) are natural or synthetic compounds that mimic the health‐promoting and longevity‐extending effects of caloric restriction. CRMs provoke the deacetylation of cellular proteins coupled to an increase in autophagic flux in the absence of toxicity. Here, we r...

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Detalhes bibliográficos

Principais autores:	Guo Chen, Wei Xie, Jihoon Nah, Allan Sauvat, Peng Liu, Federico Pietrocola, Valentina Sica, Didac Carmona‐Gutierrez, Andreas Zimmermann, Tobias Pendl, Jelena Tadic, Martina Bergmann, Sebastian J Hofer, Lana Domuz, Sylvie Lachkar, Maria Markaki, Nektarios Tavernarakis, Junichi Sadoshima, Frank Madeo, Oliver Kepp, Guido Kroemer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2019-10-01
coleção:	EMBO Molecular Medicine
Assuntos:	caloric restriction caloric restriction mimetic cardioprotection TFE3 TFEB
Acesso em linha:	https://doi.org/10.15252/emmm.201910469
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