The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identific...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Carmona-Gutierrez, Didac, Zimmermann, Andreas, Kainz, Katharina, Pietrocola, Federico, Chen, Guo, Maglioni, Silvia, Schiavi, Alfonso, Nah, Jihoon, Mertel, Sara, Beuschel, Christine B., Castoldi, Francesca, Sica, Valentina, Trausinger, Gert, Raml, Reingard, Sommer, Cornelia, Schroeder, Sabrina, Hofer, Sebastian J., Bauer, Maria A., Pendl, Tobias, Tadic, Jelena, Dammbrueck, Christopher, Hu, Zehan, Ruckenstuhl, Christoph, Eisenberg, Tobias, Durand, Sylvere, Bossut, Noélie, Aprahamian, Fanny, Abdellatif, Mahmoud, Sedej, Simon, Enot, David P., Wolinski, Heimo, Dengjel, Jörn, Kepp, Oliver, Magnes, Christoph, Sinner, Frank, Pieber, Thomas R., Sadoshima, Junichi, Ventura, Natascia, Sigrist, Stephan J., Kroemer, Guido, Madeo, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381180/
https://ncbi.nlm.nih.gov/pubmed/30783116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08555-w
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