Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target Genes

BACKGROUND: Regulatory elements may be involved in the mechanisms by which 52 loci influence myocardial mass, reflected by abnormal amplitude and duration of the QRS complex on the electrocardiogram (ECG). Functional annotation thus far did not take into account how these elements are affected in di...

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Publicat a:Circ Genom Precis Med
Autors principals: Hemerich, Daiane, Pei, Jiayi, Harakalova, Magdalena, van Setten, Jessica, Boymans, Sander, Boukens, Bas J., Efimov, Igor R., Michels, Michelle, van der Velden, Jolanda, Vink, Aryan, Cheng, Caroline, van der Harst, Pim, Moore, Jason H., Mokry, Michal, Tragante, Vinicius, Asselbergs, Folkert W.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380958/
https://ncbi.nlm.nih.gov/pubmed/30681347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.118.002328
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